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Bob Odenkirk’s Cameo Is the Key to Understanding The Bear Season 2

Bob Odenkirk’s Cameo Is the Key to Understanding The Bear Season 2

Season 2 of The Bear on Hulu included some Emmy-worthy performances from its central cast, especially Jeremy Allen White as Carmy, but the most talked-about aspect of the season was the plethora of impressive guest stars. Whether they were showing up and stealing the entire show in a single scene like Oscar-winner Olivia Colman or …

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Fewer teens now perceive themselves as overweight, finds international study of more than 745,000 adolescents

Fewer teens now perceive themselves as overweight, finds international study of more than 745,000 adolescents

Credit: CC0 Public Domain A study involving more than 745,000 adolescents from 41 countries across Europe and North America identified an increase in the amount of teenagers who underestimate their body weight. Tracking data from 2002 to 2018, the findings, published in Child and Adolescent Obesity, demonstrate a noticeable decrease in those who overestimate their …

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COVID-19 vaccination reduced disease disparities between low-income communities

COVID-19 vaccination reduced disease disparities between low-income communities

Credit: Unsplash/CC0 Public Domain COVID-19 vaccination helped reduce disparities in disease incidence between low- and high-income communities, according to a new analysis led by Cedars-Sinai investigators. While lower-income communities had lower vaccination rates than higher-income communities, the impact of vaccination on disease incidence was larger in lower-income communities. As a result, investigators say, vaccination led …

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Xeroderma pigmentosum study tests artificial antisense oligonucleotides as therapeutic

Xeroderma pigmentosum study tests artificial antisense oligonucleotides as therapeutic

Locations of the ERCC4/XPF intron variants identified in the Japanese XP-F cases. (A) Estimated structures of pre-mRNA products resulting from the ERCC4/XPF intron variants. Cryptic intron fragments identified in the patients’ mRNA are shown in blue lines. (B) cDNA sequences of the ERCC4/XPF exons 1 to 2 boundary in 48BR (normal) and XP43NG (XP-F). The …

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Breast cancer by age: Study reveals early mutations that predict patient outcomes

Breast cancer by age: Study reveals early mutations that predict patient outcomes

Credit: Pixabay/CC0 Public Domain A study led by researchers at Sanford Burnham Prebys has found that in young women, certain genetic mutations are associated with treatment-resistant breast cancer. These mutations are not linked to treatment-resistant breast cancer in older women. The findings, published in the journal Science Advances, could help improve precision medicine and suggest …

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Researchers synthesize chimeric peptide that elicits antitumor activity for cancer immunotherapy

Researchers synthesize chimeric peptide that elicits antitumor activity for cancer immunotherapy

The peptide Pal-DMPOP consists a peptide inhibitor of CD47/SIRPα, a D-peptide inhibitor of PD-1/PD-L1, and a palmitic acid tail conjugated at its N-terminal through a PEG4 linker. This design made this peptide resistant to serum proteolysis and accumulated in the tumor tissues. It can block CD47/SIRPα and PD-1/PD-L1 to enhance the phagocytosis of macrophage, and …

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