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Health and Fitness

24-Hour Urine Testing in Multiple Myeloma: Time to Stop?

SAN DIEGO — Omitting 24-hour urine testing from multiple myeloma response assessments does not compromise accurate tracking of patients’ responses to treatment, a new analysis indicates. Overall, evaluating patients’ responses using urine-free and traditional criteria led to nearly identical assessments. When comparing the two criteria, only seven of 645 patients evaluated had discordant results. The …

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Rilzabrutinib Shines in Phase 3 Trial of Tough-to-Treat ITP

SAN DIEGO — Phase 3 data support rilzabrutinib as a potential first-in-class oral Bruton tyrosine kinase (BTK) inhibitor for patients with previously treated immune thrombocytopenia (ITP).  In the LUNA 3 trial, treatment with rilzabrutinib (Sanofi) led to rapid and durable platelet responses, reduced bleeding and need for rescue therapy, and improved health-related quality of life …

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High-Fiber Diet Linked to Improved Stem Cell Transplant, GvHD Outcomes

SAN DIEGO — Recipients of allogeneic hematopoietic cell transplantation (allo-HCT) for blood disorders who maintain diets high in fiber show significant improvements in overall survival and a reduced risk of developing the potentially life-threatening complication of acute graft-versus-host disease (aGVHD), new research shows. Importantly, the findings suggest standard recommendations for patients of a low-fiber diet …

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IVIG Prophylaxis in Myeloma Cuts Infections, Ups Survival

SAN DIEGO — Patients with multiple myeloma who receive intravenous immunoglobulin (IVIG) prophylaxis during treatment with teclistamab have fewer infections and better overall survival compared with those who do not receive IVIG prophylaxis, according to new findings presented here at the American Society of Hematology (ASH) 2024 Annual Meeting. Among 225 consecutive patients who received …

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With Chemo, Blinatumomab Boosts DFS in Pediatric B-ALL

SAN DIEGO — The addition of the bispecific T-cell engager blinatumomab (Blincyto) to chemotherapy greatly boosted 3-year disease-free survival (DFS) in younger pediatric patients with newly diagnosed, standard-risk B-cell acute lymphoblastic leukemia (B-ALL), in a phase 3 randomized trial.  Among pediatric patients with B-ALL followed for a mean of 2.5 years (1.6-3.2 years), 718 patients …

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