There was no higher risk of heart attack for recipients of the two-dose hepatitis B cytosine phosphoguanine adjuvant vaccine (Heplisav-B) compared to the three-dose hepatitis B vaccine with an aluminum hydroxide adjuvant (Engerix-B), a prospective study found.
Among nearly 70,000 adults who received at least one hepatitis B vaccine dose, type 1 acute myocardial infarctions (MIs) occurred at a rate of 1.67 per 1,000 person-years for those who received the two-dose vaccine and 1.86 per 1,000 person-years for recipients of the three-dose vaccine, which met noninferiority criteria (adjusted HR 0.92, one-sided 97.5% CI ∞ to 1.32, P