Poor sleep patterns and high genetic susceptibility together doubled the risk of asthma development in adults, a prospective study using U.K. Biobank data found.
Individuals in the study who had the highest polygenic risk score (PRS) or were poor sleepers had a 47-55% higher risk for asthma over a median 8 years of follow-up compared with their lower-risk counterparts (low PRS or healthy sleep, respectively), according to Fuzhong Xue, MD, PhD, of the Cheeloo College of Medicine at Shandong University in Jinan, China, and colleagues.
But individuals with both of these risk factors together saw their risk more than double (HR 2.22, 95% CI 1.97-2.49, P