A reduced-dose schedule of cabazitaxel (Jevtana) plus prophylactic granulocyte colony-stimulating factor (G-CSF) should be offered to older men with metastatic castration-resistant prostate cancer (mCRPC), according to results from the phase III randomized CABASTY trial.
Rates of grade 3 or higher neutropenia or neutropenic complications were about 12 times lower with biweekly cabazitaxel 16 mg/m2 plus G-CSF compared with the standard regimen of triweekly cabazitaxel 25 mg/m2 plus G-CSF (5.1% vs 62.5%; OR 0.03, 95% CI 0.01-0.08, P